Application of trifluoromethyl pyridine in insecticides and antagonists

2-Hydroxy-3-trifluoromethylpyridine is a widely used organic intermediate, not only for the synthesis of nicotinic insecticides, antagonist TRPV1, anti-androgen A52, but also for the synthesis of various drugs. 2-Hydroxy-3-trifluoromethylpyridine's physical and chemical information is shown as follows:

 

Physicochemical information of 2-hydroxy-3-trifluoromethylpyridine

Structural formula        

CAS# 22245-83-6

Appearance

White to off-white powder

Melting point

150-153℃

Boiling point

224℃

Flash point

89℃

Molecular formula

C6H4F3NO

Molecular weight

163.10

Solubility

Soluble in water, ethanol, ethyl acetate and other solvents

 

Application of 2-hydroxy-3-trifluoromethylpyridine in insecticides and antagonists and in the preparation of other pharmaceutical compositions

3-TRIFLUOROMETHYLPYRIDINE

 

The quality specification of the product is shown as follows:

Quality specification of 2-hydroxy-3-trifluoromethylpyridine

CAS#

2927-71-1

Appearance

Off-white solid

Purity ≥98%

Monohybrid ≤1%

 

1. Packaging and storage properties

1.1 Package: Fluorinated bottle, aluminum foil bag and cardboard drum

1.2 Storage: Keep the container airtight and store in a dry, ventilated and cool place.

 

2. Exposure hazard and control

2.1 Causes skin irritation and causes severe eye irritation.

2.2 Handle in a well-ventilated place. Wear suitable protective gear. Prevent dust from spreading. Wash hands thoroughly after handling.

 

Application of 2-hydroxy-3-trifluoromethylpyridine in insecticides and antagonists and in the preparation of other pharmaceutical compositions

 

3. Emergency treatment

3.1 First aid measures

Inhalation: Move the victim to fresh air, keep breathing open and rest. If feeling unwell seek medical attention/consultation.   

Skin contact: Immediately remove/remove all contaminated clothing. Wash gently with plenty of soap and water. If skin irritation or rash occurs: Seek medical attention/consultation.

Eye contact: Wash carefully with water for several minutes. If convenient and easy to do, remove contact lenses. Continue washing. If eye irritation: Seek medical attention/consultation.

Ingestion: If discomfort occurs, seek medical attention/consultation. Rinse mouth.   

Emergency responder protection: Rescuers need to wear personal protective equipment, such as rubber gloves and airtight goggles.

 

Application of 2-hydroxy-3-trifluoromethylpyridine in insecticides and antagonists and in the preparation of other pharmaceutical compositions

 

3.2 Fire Fighting Measures

Suitable extinguishing agents: dry powder, foam, fog water, carbon dioxide   

Special hazards: Caution, burning or high temperature may decompose to produce toxic smoke.

Specific method: Extinguish the fire from upwind, choose the suitable fire extinguishing method according to the surrounding environment.   

Non-relevant personnel should evacuate to a safe place.

Once the surrounding area is on fire: If safe, remove removable containers.

Special protective gear for firefighters: Always wear personal protective equipment when extinguishing a fire.

More please contact Huimeng

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